The 'Delta Plus' AY.4.2 Coronavirus Variant Is Rising in the U.K.

A coronavirus variant called AY.4.2, which is a mutation of the Delta variant, has been identified in the United Kingdom. It could be more infectious than Delta, but experts say we need more data.

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  • Experts are monitoring the coronavirus variant AY.4.2, currently spreading in the U.K.
  • According to the latest official data, AY.4.2, also called “Delta Plus,” has been identified in about 6 percent of cases in the U.K.
  • There may be some early evidence it’s more infectious, but more data is needed.

The coronavirus has continued to mutate and change as it has spread across the globe in the last 2 years.

The most concerning new variant of the coronavirus is an offshoot of the Delta variant called AY.4.2.

It’s currently spreading in the United Kingdom and has confirmed presence in the United States, health officials said at a White House briefing.

“Variants are changes to the virus that occur at random,” Dr. Eric Cioe-Peña, director of global health at Northwell Health in New Hyde Park, New York, told Healthline. “When they give a replication advantage to the virus, they become dominant.”

According to the latest official data, AY.4.2, also called “Delta Plus,” has been identified in about 6 percent of cases in the United Kingdom.

Possibly more infectious

Data suggests AY.4.2 could be 10 percent more transmissible than the most common U.K. Delta variant, AY.4, Francois Balloux, PhD, director at the University College London Genetics Institute, posted to social media.

The Centers for Disease Control and Prevention (CDC) says the Delta variant is highly contagious and more resistant to treatment than the original variant.

A 10 percent increase could make the new variant the most infectious yet.

However, experts say that more infectious doesn’t necessarily mean greater cause for concern.

“Well, transmissible does not mean more dangerous,” said Dr. Len Horovitz, internist and pulmonary specialist at Lenox Hill Hospital in New York. “Doesn’t mean more virulent.”

He explained what it does mean is that the virus’s incubation period is shorter, so it can be transmitted faster and spread more easily than one that requires longer incubation.

“Transmissibility does not equate with virulence,” he emphasized. “So we don’t know if these cases will be more serious.”

Vaccines are effective against this variant

Horovitz confirmed it’s unlikely that the Delta Plus variant can evade all vaccine-related immunity.

“That’s pretty clear that [it] would have to have a lot more variation,” he said. “A lot more mutation in this virus before it could evade vaccines. So, that’s not particularly a worry.”

The variant’s potential infectiousness means we could see a significant increase in cases, which could lead to more people with serious disease.

“When there are more cases there’s more chance of complications, more chance of hospitalizations,” Horovitz said. “But again, the vaccines are protecting against hospitalization and death.”

He added that while he doesn’t expect that to change too much, “we may have more cases, more downtime, more people isolated, or disruption.”

Booster shots and AY.4.2

Experts say not only are the current COVID-19 vaccines still highly effective, but our immune systems may be more powerfully stimulated by vaccination than we think.

“We have more memory in the memory B cells and memory T cells in our bone marrow than we measure by looking at peripheral antibodies,” Horovitz said.

But this doesn’t mean booster shots aren’t important.

“We’ve all committed to boosters, and we should commit to boosters because that’s just what’s been set out for us,” Horovitz said. “And the booster, these vaccines will cover the mutations that we’ve seen thus far.”

He also said that there would have to be “a lot more” mutations in the virus before we worry that the vaccines need to be changed in response.

Vaccination is more important than booster shots

Cioe-Peña said that getting every adult vaccinated is more important than boosters, which may only slightly help prevent a surge.

According to Cioe-Peña, this needs to be done through education, incentives, and mandates.

“Vaccinating 5- to 11-year-olds will also help a lot, but the key is vaccinating adults that have not yet received one dose of vaccine,” he said. “If the U.S. does not vaccinate its entire population, this problem will not go away.”

However, Cioe-Peña added that AY.4.2 doesn’t seem to be much more of a threat than Delta variant at this time.

“But Delta is such a significant threat that it’s hard to imagine a variant that’s more infectious,” he said.

The bottom line

A coronavirus variant called AY.4.2, which is a mutation of the Delta variant, has been identified in the United Kingdom, and it could be more infectious than Delta.

Experts say that more infectious doesn’t mean more dangerous, though, and that current vaccines are highly effective against the currently circulating variants.

They also say that vaccinating everyone is the best way to protect against COVID-19, and without universal vaccination, the pandemic won’t end.

This story originally appeared on: Healthline.com - Author:George Citroner